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Fabrication and in vitro degradation study of novel optically Active polymers derived from amino acid containing diacids and 4,4΄-thiobis(2-tert-butyl-5-methylphenol).

ABSTRACT

Chiral bioactive poly(ester-imide)s (PEI)s were synthesized from N,N′-(pyromellitoyl)-bis-(L-phenylalanine) and N,N′-(pyromellitoyl)-bis-(L-leucine) diacids derived from amino acids with 4,4′-thiobis(2-tert-butyl-5-methylphenol) via direct polycondensation reaction in a system of tosyl chloride, pyridine and N,N-dimethylformamide as a condensing agent. The structures of these polymers were confirmed by FT-IR, 1H-NMR, specific rotation, elemental and thermogravimetric analysis (TGA) techniques. TGA showed that the 10% weight loss temperature in a nitrogen atmosphere was more than 390 °C, which indicates that the resulting PEIs have a good thermal stability. The biodegradability of the monomers and prepared polymers was investigated in culture media and soil burial test for assessing the susceptibility of these compounds to microbial degradation. The results showed that the synthesized monomers and theirs
derived polymers are biologically active and they are nontoxic to microbial growth.